Dr Sacha Zeerleder, MD, PhD

Dr Sacha Zeerleder, MD, PhD

Academic Medical Center, Amsterdam,
The Netherlands

Sacha Zeerleder is an Internist-Haematologist at the Academic Medical Center in Amsterdam (The Netherlands). He is the Director of the haematopoietic stem cell transplantation programme and Medical Head of the special haematology and transfusion laboratory of the Academic Medical Center.

Dr Zeerleder obtained his medical degree at the University of Berne (Switzerland) in 1997. He trained as an Internist Haematologist in different university and district hospitals in Switzerland and at the Academic Medical Center in Amsterdam. In 1999 he completed his doctoral thesis on thromboembolism in congenital factor XII deficiency at the University of Berne, and in 2007 his PhD thesis on inflammation and coagulation pathways in sepsis at the University of Amsterdam. Since 2010 Dr Zeerleder has been a senior staff haematologist at the Academic Medical Center in Amsterdam. He is also a senior staff member at the department of immunopathology at Sanquin Research in Amsterdam.

His research is dedicated to the role of innate immunity in haematological diseases. This mainly includes studies on the mechanisms by which damage associated molecular patterns (DAMPs) are released, the regulation thereof, and how they induce systemic inflammation with a special interest in the role of plasma proteins (complement, coagulation) and plasma inhibitors herein. To study these concepts the main focus lies on diseases of systemic inflammation, such as systemic lupus erythematosus and sepsis, graft-vs-host disease, autoimmune haemolytic anaemia, paroxysmal haemoglobinuria and sickle cell disease.


Grants/Research Support: Viropharma
Meeting Honorarium/Expenses: Alexion

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