Dr Elizabeth Jury, PhD

Dr Elizabeth Jury, PhD

University College London,
United Kingdom

Elizabeth Jury is a Principal Research Associate and Arthritis Research UK Career Progression Fellow at the Centre for Rheumatology Research, University College London. Dr Jury started her career at St Bartholomew’s Hospital developing the Immunopathology service specialising in the diagnosis of autoimmunity, immunodeficiency and immunophenotyping. She moved to a more research-focused career joining Professor David Isenberg’s team in 2000 and now leads her own research group. Dr Jury’s work has developed new areas of research into signalling abnormalities in T and B cells from patients with systemic lupus erythematosus (SLE) and has made a significant contribution towards understanding the nature of these abnormalities and how they relate to disease pathogenesis. The main focus of her research is to understand the role of plasma membrane and cellular and serum lipids on immune cell activation. Dr Jury was one of the first to identify defects in plasma membrane lipids in T cells from patients with SLE and her recent work has identified a defect in lipid metabolism that results in increased levels of a particular type of lipid called glycosphingolipids (GSLs). Furthermore, she found inhibiting GSL biosynthesis using a clinically approved inhibitor restored correct lipid metabolism and corrected functional defects in T cells from SLE patients. This work provides an emerging picture of a possible underlying defect in lipid metabolism in SLE patients and supports further the hypothesis that targeting lipid biosynthesis pathways could be a novel therapeutic strategy for SLE.

Disclosures

None

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